Questão de Saúde

Acute Promyelocytic Leukemia (Acute Myeloid LeukemiaMM3) is characterized by its cytogenetic morphologic and molecular characteristics. Regarding this disease, consider the statements below. I M Cytogenetically is characterized by a balanced translocation between PML gen on chromosome 15 and the RARA α gene on chromosome 17. II M The underlying translocation t(15;17) leads to formation of the PMLMRAR and causes maturation arrest in the promyelocyte stage. III M Anthracyclines are associated to cytarabine t o improve complete remission rates in newly diagnosed patients. IV M Coagulopathy and hemorrhage are not seen in M3v subtype. V M ATRA (Trans Retinoic Acid) induces the differentiation of leukemic blasts into imature granulocytes. Wich ones are correct?